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SAR445399 in Adults With Non-Cystic Fibrosis Bronchiectasis (PDY19372)

A Phase 2a study of SAR445399 compared with placebo in adults 18 to 80 with non-cystic fibrosis bronchiectasis, measuring mucus plugging on chest CT.

Phase 2Phase
Active · not recruitingStatus
NCT07547436 ↗ClinicalTrials.gov

About the study

This Phase 2a study is evaluating SAR445399, an investigational treatment, compared with placebo in adults with non-cystic fibrosis bronchiectasis. The main measure is the change in mucus plugging of the airways seen on a high-resolution chest CT scan after 24 weeks. Lung function and flare-ups of bronchiectasis are also tracked.

Who took part

The study enrolled people who:

  • Were 18 to 80 years old
  • Had bronchiectasis confirmed on chest CT, with daily mucus production
  • Had at least 2 flare-ups treated with antibiotics in the prior year

Status at Veritas

This study is active but no longer enrolling new participants. People already enrolled continue their study visits.

Learn more

The full study record, including all eligibility criteria and outcome measures, is on ClinicalTrials.gov (NCT07547436).

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