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Itepekimab (Anti-IL-33) Proof-of-Concept Study in Non-Cystic Fibrosis Bronchiectasis

A Phase 2 proof-of-concept study of itepekimab compared with placebo for reducing flare-ups in adults with non-cystic fibrosis bronchiectasis.

Phase 2Phase
CompletedStatus
NCT06280391 ↗ClinicalTrials.gov

About the study

This Phase 2 proof-of-concept study (ACT18018) evaluated two dosing regimens of itepekimab, an investigational anti-IL-33 antibody, compared with placebo in adults with non-cystic fibrosis bronchiectasis. The main goal was to see whether it reduced the rate of moderate or severe flare-ups over 24 to 52 weeks of treatment.

Who took part

The study enrolled people who:

  • Were 18 to 85 years old
  • Had non-cystic fibrosis bronchiectasis with at least 2 moderate or 1 severe flare-up in the prior year

Status at Veritas

This study has been completed. It is no longer enrolling, and it is listed here as part of Veritas Clinical Research's track record as a research site.

Learn more

The full study record, including all eligibility criteria and outcome measures, is on ClinicalTrials.gov (NCT06280391).

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